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Serotonin Syndrome Symptoms'

Easily annoyed, Craze, Loss of consciousness, Fits, Restlessness, Increased heart rate, Perspiration, Shivering, Tremor, Mental status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Shaking, Pain in the abdomen, Diarrhea, Perspiration, Increased heat, Hypertension. All these are symptoms of serotonin syndrome. Just about all may appear typically in the 1st 24 hours right after taking a particular o.d. of serotonin drugs. This symptoms tend to be on mental processes level, visceral worried system level and SoNS stage. Serotonin Toxidrome come often right after overdose of serotonin drugs and drug combination that increase synaptic serotonin. Drugs that are know to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Amphetamine, Sibutramine, Cocaine, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Li, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Pep pill. For the reason that serotonin syndrome it's not tested in the laboratory for diagnosis, signs tend to be the one that need noticed. The number one set of criteria to use to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.

Treatment for serotonin syndrome tend to be as follows: discontinuing drugs that made the overdose posible as well as drugs that can lead management of serotonin antagonist (eg. cyproheptadine) for sever cases of toxicity for agitation, muscle mass hardness and seizure such as movements, benzodiazepines (Valium, Ativan) Intra venous fluids Because serotonin syndrome is certainly not easy to diagnose, prevention is required for any kind of serotonin drugs combination that may cause serotonin toxicity.


Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642 Prator BC. Serotonin syndrome. J Neurosci Nurs. 2006 Apr;38(2):102-5. Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.

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